› 3o2x

X-ray diffraction
1.9Å resolution

MMP-13 in complex with selective tetrazole core inhibitor

Released:
DOI: 10.2210/pdb3o2x/pdb
PDB entry 3o2x coloured by chain, front view.
PDB entry 3o2x coloured by chain, side view.
PDB entry 3o2x coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kiefer JR, Barta TE, Becker DP, Mathis KJ, Williams J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 18.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 105-267; Coverage: 36%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

5 bound ligands:
Ligand 3O2 4 x 3O2
Ligand ZN 8 x ZN
Ligand CA 8 x CA
Ligand SO4 9 x SO4
Ligand EPE 2 x EPE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 73.864Å b: 95.257Å c: 120.076Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.21
Expression system: Escherichia coli

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