› 3pdz

Solution NMR

SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E

Released:
DOI: 10.2210/pdb3pdz/pdb
PDB entry 3pdz coloured by chain, ensemble of 30 models, front view.
PDB entry 3pdz coloured by chain, ensemble of 30 models, side view.
PDB entry 3pdz coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor.
Kozlov G, Gehring K, Ekiel I
Biochemistry 39 2572-80 (2000)
PMID: 10704206

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 13 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q12923 (Residues: 1361-1456; Coverage: 4%)
Gene names: PNP1, PTP1E, PTPL1, PTPN13
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

PDZ domains and the organization of supramolecular complexes.
Sheng et al. (2001)
4 more

15 mentions without citation

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
Bhat et al. (2018)
14 more