› 3q7j

X-ray diffraction
2.91Å resolution

Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development

Released:
DOI: 10.2210/pdb3q7j/pdb
PDB entry 3q7j coloured by chain, front view.
PDB entry 3q7j coloured by chain, side view.
PDB entry 3q7j coloured by chain, top view.
Source organism: Thermoplasma acidophilum DSM 1728
Primary publication:
Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.
Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L
Bioorg Med Chem 19 2991-6 (2011)
PMID: 21493078

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tricorn protease-interacting factor F3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 780 amino acids
Theoretical weight: 89.48 KDa
Source organism: Thermoplasma acidophilum DSM 1728
Expression system: Escherichia coli
UniProt:
  • Canonical: O93655 (Residues: 1-780; Coverage: 100%)
Gene names: Ta0815, trf3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand FBO 1 x FBO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 114.717Å b: 183.101Å c: 105.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.202 0.271
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.
Zhang et al. (2014)
5 more

2 mentions without citation

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families.
Pascual Alonso et al. (2023)
1 more