› 3qg6

X-ray diffraction
2.5Å resolution

Structural Basis for Ligand Recognition and Discrimination of a Quorum Quenching Antibody

Released:
DOI: 10.2210/pdb3qg6/pdb
PDB entry 3qg6 coloured by chain, front view.
PDB entry 3qg6 coloured by chain, side view.
PDB entry 3qg6 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for ligand recognition and discrimination of a quorum-quenching antibody.
Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA
J Biol Chem 286 17351-8 (2011)
PMID: 21454495

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212716 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
AP4-24H11 Light Chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 218 amino acids
Theoretical weight: 24.14 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
AP4-24H11 Heavy Chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 213 amino acids
Theoretical weight: 23.05 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Agr autoinducing peptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 8 amino acids
Theoretical weight: 1.03 KDa
Source organism: Staphylococcus aureus
Expression system: Not provided
UniProt:
  • Canonical: Q9F6Z3 (Residues: 25-32; Coverage: 17%)
Gene name: agrD

Ligands and Environments

2 bound ligands:
Ligand ZN 9 x ZN
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 68.36Å b: 98.498Å c: 73.67Å
α: 90° β: 114.03° γ: 90°
R-values:
R R work R free
0.186 0.184 0.239
Expression systems:
  • Mus musculus
  • Not provided

Quick links

Citations

10 review citations

Staphylococcus aureus pathogenesis in diverse host environments.
Balasubramanian et al. (2017)
9 more

3 mentions without citation

Antibody-Mediated Catalysis in Infection and Immunity.
Bowen et al. (2017)
2 more