› 3qu0

X-ray diffraction
1.95Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand X40 1 x X40
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 53.37Å b: 71.66Å c: 72.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.251
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Mitigating risk in academic preclinical drug discovery.
Dahlin et al. (2015)
4 more

2 mentions without citation

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Schonbrunn et al. (2013)
1 more