3r5m

X-ray diffraction
2.8Å resolution

Crystal structure of RXRalphaLBD complexed with the agonist magnolol

Released:
Source organism: Homo sapiens
Primary publication:
Molecular determinants of magnolol targeting both RXRα and PPARγ.
OpenAccess logo PLoS One 6 e28253 (2011)
PMID: 22140563

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-148727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 10 amino acids
Theoretical weight: 1.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 687-696; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 65.95Å b: 65.83Å c: 110.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.249 0.293
Expression systems:
  • Escherichia coli
  • Not provided