› 3rg1

X-ray diffraction
2.91Å resolution

Crystal structure of the RP105/MD-1 complex

Released:
DOI: 10.2210/pdb3rg1/pdb
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PDB entry 3rg1 coloured by chain, front view.
PDB entry 3rg1 coloured by chain, side view.
PDB entry 3rg1 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.
Yoon SI, Hong M, Wilson IA
Nat Struct Mol Biol 18 1028-35 (2011)
PMID: 21857663

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107328 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
LRRCT domain-containing protein Chains: A, B, E, F, I, J, M, N
Molecule details ›
Chains: A, B, E, F, I, J, M, N
Length: 612 amino acids
Theoretical weight: 68.87 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A6QNK7 (Residues: 24-626; Coverage: 94%)
Gene name: CD180
Sequence domains:
Structure domains: Ribonuclease Inhibitor
MD-2-related lipid-recognition domain-containing protein Chains: C, D, G, H, K, L, O, P
Molecule details ›
Chains: C, D, G, H, K, L, O, P
Length: 147 amino acids
Theoretical weight: 16.5 KDa
Source organism: Bos taurus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A4IFT3 (Residues: 21-159; Coverage: 100%)
Gene name: LY86
Sequence domains: ML domain
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand PGT 4 x PGT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 101.509Å b: 141.577Å c: 141.953Å
α: 94° β: 91.66° γ: 91.37°
R-values:
R R work R free
0.24 0.238 0.276
Expression system: Spodoptera frugiperda

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Citations

15 review citations

Recognition of lipopolysaccharide pattern by TLR4 complexes.
Park et al. (2013)
14 more

3 mentions without citation

An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.
Yoon et al. (2011)
2 more

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