Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Translational (tr)-type GTP-binding domain
- Translation initiation factor IF2/IF5 domain
- Translation initiation factor 2, alpha subunit, C-terminal
- Translation initiation factor 2, alpha subunit, middle domain superfamily
- S1 domain
- Translation initiation factor 2, alpha subunit
- Nucleic acid-binding, OB-fold
- Initiation factor eIF2 gamma, C-terminal
15 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Translation initiation factor 2 and tRNA (preferred)
PDBe Complex ID:
PDB-CPX-250380 (preferred)
Entry contents:
3 distinct polypeptide molecules
1 distinct RNA molecule
1 distinct RNA molecule
Macromolecules (4 distinct):
Translation initiation factor 2 subunit gamma
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 45.72 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
Sequence domains:
Length: 414 amino acids
Theoretical weight: 45.72 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q980A5 (Residues: 2-415; Coverage: 100%)
Sequence domains:
Translation initiation factor 2 subunit alpha
Molecule details ›
Chain: B
Length: 266 amino acids
Theoretical weight: 30.43 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
Sequence domains:
Length: 266 amino acids
Theoretical weight: 30.43 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q97Z79 (Residues: 1-266; Coverage: 100%)
Sequence domains:
Translation initiation factor 2 subunit beta
Molecule details ›
Chain: C
Length: 138 amino acids
Theoretical weight: 15.81 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Domain found in IF2B/IF5
Length: 138 amino acids
Theoretical weight: 15.81 KDa
Source organism: Saccharolobus solfataricus P2
Expression system: Escherichia coli BL21
UniProt:
- Canonical: Q97W59 (Residues: 2-139; Coverage: 99%)
Sequence domains: Domain found in IF2B/IF5
