3vq1

X-ray diffraction
2.7Å resolution

Crystal structure of mouse TLR4/MD-2/lipid IVa complex

Released:
Source organism: Mus musculus
Primary publication:
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Proc Natl Acad Sci U S A 109 7421-6 (2012)
PMID: 22532668

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-191590 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Toll-like receptor 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 606 amino acids
Theoretical weight: 68.71 KDa
Source organism: Mus musculus
Expression system: Drosophila
UniProt:
  • Canonical: Q9QUK6 (Residues: 22-627; Coverage: 74%)
Gene names: Lps, Tlr4
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor
Lymphocyte antigen 96 Chains: C, D
Molecule details ›
Chains: C, D
Length: 144 amino acids
Theoretical weight: 16.63 KDa
Source organism: Mus musculus
Expression system: Drosophila
UniProt:
  • Canonical: Q9JHF9 (Residues: 17-160; Coverage: 100%)
Gene names: Esop1, Ly96, Md2
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 77.16Å b: 150.519Å c: 181.847Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.277
Expression system: Drosophila