› 3w8s

X-ray diffraction
2.07Å resolution

Crystal structure of monomeric Na-GST-3, a glutathione s-transferase from the major human hookworm parasite Necator americanus

Released:
DOI: 10.2210/pdb3w8s/pdb
PDB entry 3w8s coloured by chain, front view.
PDB entry 3w8s coloured by chain, side view.
PDB entry 3w8s coloured by chain, top view.
Source organism: Necator americanus
Primary publication:
Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus.
Kelleher A, Zhan B, Asojo OA
Acta Crystallogr Sect F Struct Biol Cryst Commun 69 839-43 (2013)
PMID: 23908024

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112554 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase-3 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.64 KDa
Source organism: Necator americanus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: D3U1A7 (Residues: 1-206; Coverage: 100%)
Gene name: gst-3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GSH 1 x GSH
Ligand SO4 1 x SO4
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P43212
Unit cell:
a: 67.12Å b: 67.12Å c: 134.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.22
Expression system: Komagataella pastoris

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Citations

2 citation in other articles

A combined biochemical and computational studies of the rho-class glutathione s-transferase sll1545 of Synechocystis PCC 6803.
Pandey et al. (2017)
1 more

2 mentions without citation

Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus.
Kelleher et al. (2013)
1 more