Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(27) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(27) + succinate + formaldehyde + CO(2)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Histone demethylase UTY (preferred)
PDBe Complex ID:
PDB-CPX-127019 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone demethylase UTY
Molecule details ›
Chains: A, B
Length: 478 amino acids
Theoretical weight: 55.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 478 amino acids
Theoretical weight: 55.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
O14607 (Residues: 878-1347; Coverage: 35%)
Sequence domains:
- JmjC domain, hydroxylase
- Lysine-specific demethylase 6/UTY, C-terminal helical domain
- KDM6, GATA-like
