› 3zs0

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138574 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Myeloperoxidase light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 12.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05164 (Residues: 165-272; Coverage: 16%)
Gene name: MPO
Myeloperoxidase heavy chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 467 amino acids
Theoretical weight: 53.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05164 (Residues: 279-745; Coverage: 67%)
Gene name: MPO
Sequence domains: Animal haem peroxidase
Structure domains: Haem peroxidase domain superfamily, animal type

Ligands and Environments


Cofactor: Ligand HEM 2 x HEM
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
6 bound ligands:
Ligand SO4 3 x SO4
Ligand ZS0 2 x ZS0
Ligand NAG 4 x NAG
Ligand CA 2 x CA
Ligand CL 2 x CL
Ligand ACT 6 x ACT
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21
Unit cell:
a: 93.905Å b: 64.111Å c: 111.452Å
α: 90° β: 97.12° γ: 90°
R-values:
R R work R free
0.172 0.17 0.207

Quick links

Citations

22 review citations

Reactive Oxygen Species and Neutrophil Function.
Winterbourn et al. (2016)
21 more