› 3zuo

X-ray diffraction
1.86Å resolution

OMCI in complex with leukotriene B4

Released:
DOI: 10.2210/pdb3zuo/pdb
PDB entry 3zuo coloured by chain, front view.
PDB entry 3zuo coloured by chain, side view.
PDB entry 3zuo coloured by chain, top view.
Source organism: Ornithodoros moubata
Primary publication:
Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.
Roversi P, Ryffel B, Togbe D, Maillet I, Teixeira M, Ahmat N, Paesen GC, Lissina O, Boland W, Ploss K, Caesar JJ, Leonhartsberger S, Lea SM, Nunn MA
OpenAccess logo J Biol Chem 288 18789-802 (2013)
PMID: 23625922

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement inhibitor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 150 amino acids
Theoretical weight: 16.8 KDa
Source organism: Ornithodoros moubata
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q5YD59 (Residues: 19-168; Coverage: 100%)
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand LTB 4 x LTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 41.756Å b: 112.789Å c: 62.394Å
α: 90° β: 101.89° γ: 90°
R-values:
R R work R free
0.221 0.22 0.238
Expression system: Escherichia coli K-12

Quick links

Citations

6 review citations

Animal venoms/toxins and the complement system.
Tambourgi et al. (2014)
5 more

5 mentions without citation

Decoding the chemotactic signal.
Thomas et al. (2018)
4 more