4ae9

X-ray diffraction
2.3Å resolution

Structure and function of the Human Sperm-Specific Isoform of Protein Kinase A (PKA) Catalytic Subunit C alpha 2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-148112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-dependent protein kinase catalytic subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 343 amino acids
Theoretical weight: 40.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P17612 (Residues: 10-351; Coverage: 97%)
  • Best match: P17612-2 (Residues: 1-343)
Gene names: PKACA, PRKACA
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 76.396Å b: 89.971Å c: 115.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.264
Expression system: Escherichia coli BL21