› 4b7u

X-ray diffraction
1.88Å resolution

PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH BICINE

Released:
DOI: 10.2210/pdb4b7u/pdb
PDB entry 4b7u coloured by chain, front view.
PDB entry 4b7u coloured by chain, side view.
PDB entry 4b7u coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Birkinshaw RW, Brady RL

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 322 amino acids
Theoretical weight: 34.98 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q71T02 (Residues: 1-316; Coverage: 100%)
Gene names: LDH, LDH-P, ldh
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 4 x CA
Ligand BCN 8 x BCN
Ligand MPD 1 x MPD
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21212
Unit cell:
a: 155.29Å b: 154.779Å c: 58.906Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.201
Expression system: Escherichia coli

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