› 4c0t

X-ray diffraction
3.16Å resolution

Candida albicans PKh Kinase Domain

Released:
DOI: 10.2210/pdb4c0t/pdb
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PDB entry 4c0t coloured by chain, front view.
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PDB entry 4c0t coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
PIF-pocket as a target for C. albicans Pkh selective inhibitors.
Pastor-Flores D, Schulze JO, Bahí A, Giacometti R, Ferrer-Dalmau J, Passeron S, Engel M, Süss E, Casamayor A, Biondi RM
ACS Chem Biol 8 2283-92 (2013)
PMID: 23911092

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PKH2 Chain: A
Molecule details ›
Chain: A
Length: 974 amino acids
Theoretical weight: 110.09 KDa
Source organism: Candida albicans SC5314
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5A3P6 (Residues: 1-944; Coverage: 100%)
Gene names: CAALFM_C112410CA, CaO19.12690, CaO19.5224, PKH1, PKH2, orf19.5224
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P42212
Unit cell:
a: 100.21Å b: 100.21Å c: 60.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.28
Expression system: Spodoptera frugiperda

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Citations

2 review citations

AGC kinases, mechanisms of regulation ‎and innovative drug development.
Leroux et al. (2018)
1 more

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