› 4cmn

X-ray diffraction
3.13Å resolution

Function and Biology Details

Reactions catalysed: 
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169646 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol polyphosphate 5-phosphatase OCRL Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 41.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01968 (Residues: 215-560; Coverage: 38%)
Gene names: OCRL, OCRL1
Sequence domains: Endonuclease/Exonuclease/phosphatase family
Structure domains: Endonuclease/exonuclease/phosphatase

Ligands and Environments

3 bound ligands:
Ligand PO4 1 x PO4
Ligand MG 1 x MG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P4132
Unit cell:
a: 146.766Å b: 146.766Å c: 146.766Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.21 0.263
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The extended human PTPome: a growing tyrosine phosphatase family.
Alonso et al. (2016)
4 more

10 mentions without citation

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.
Wiessner et al. (2017)
9 more