Function and Biology Details
Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Signal transduction histidine kinase-related protein, C-terminal
- Histidine kinase/HSP90-like ATPase domain
- Histidine kinase/HSP90-like ATPase superfamily
- Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
- HAMP domain
- Histidine kinase domain
- Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128062 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HAMP domain-containing protein; Sensor histidine kinase EnvZ
Molecule details ›
Chains: A, B, C, D
Length: 273 amino acids
Theoretical weight: 30.2 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 273 amino acids
Theoretical weight: 30.2 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical:
O28769 (Residues: 278-327; Coverage: 15%) - Canonical: P0AEJ4 (Residues: 229-450; Coverage: 49%)
Sequence domains:
- HAMP domain
- His Kinase A (phospho-acceptor) domain
- Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X10SA
Spacegroup:
P21
Expression system: Escherichia coli
