› 4cyv

X-ray diffraction
2.3Å resolution

Structure of the A_mallard_Sweden_51_2002 H10 Avian Haemmaglutinin

Released:
DOI: 10.2210/pdb4cyv/pdb
PDB entry 4cyv coloured by chain, front view.
PDB entry 4cyv coloured by chain, side view.
PDB entry 4cyv coloured by chain, top view.
Source organism: Influenza A virus (A/mallard/Sweden/51/2002(H10N2))
Primary publication:
Receptor binding by H10 influenza viruses.
Vachieri SG, Xiong X, Collins PJ, Walker PA, Martin SR, Haire LF, Zhang Y, McCauley JW, Gamblin SJ, Skehel JJ
Nature 511 475-7 (2014)
PMID: 24870229

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122732 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 324 amino acids
Theoretical weight: 35.32 KDa
Source organism: Influenza A virus (A/mallard/Sweden/51/2002(H10N2))
UniProt:
  • Canonical: E0YNJ7 (Residues: 17-340; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 172 amino acids
Theoretical weight: 19.77 KDa
Source organism: Influenza A virus (A/mallard/Sweden/51/2002(H10N2))
UniProt:
  • Canonical: E0YNJ7 (Residues: 341-512; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 6 x NAG
Ligand EDO 18 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 67.612Å b: 227.989Å c: 68.716Å
α: 90° β: 110.32° γ: 90°
R-values:
R R work R free
0.216 0.214 0.252

Quick links

Citations

6 review citations

Cross-species transmission and emergence of novel viruses from birds.
Chan et al. (2015)
5 more

1 mention without citation

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?
Schneider et al. (2017)