› 4dsa

X-ray diffraction
3.25Å resolution

Crystal Structure of DPP-IV with Compound C1

Released:
DOI: 10.2210/pdb4dsa/pdb
PDB entry 4dsa coloured by chain, front view.
PDB entry 4dsa coloured by chain, side view.
PDB entry 4dsa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xiong B, Zhu LR, Chen DQ, Zhao YL, Jiang F, Shen JK

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 728 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P27487 (Residues: 39-766; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand D1C 1 x D1C
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P32
Unit cell:
a: 78.676Å b: 78.676Å c: 289.849Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.198 0.266
Expression system: Homo sapiens

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