› 4dvb

X-ray diffraction
1.93Å resolution

The crystal structure of the Fab fragment of pro-uPA antibody mAb-112

Released:
DOI: 10.2210/pdb4dvb/pdb
PDB entry 4dvb coloured by chain, front view.
PDB entry 4dvb coloured by chain, side view.
PDB entry 4dvb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Rezymogenation of active urokinase induced by an inhibitory antibody.
Jiang L, Botkjaer KA, Andersen LM, Yuan C, Andreasen PA, Huang M
Biochem J 449 161-6 (2013)
PMID: 23016918

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213453 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab fragment of pro-uPA antibody mAb-112 Chains: A, H
Molecule details ›
Chains: A, H
Length: 213 amino acids
Theoretical weight: 23 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Fab fragment of pro-uPA antibody mAb-112 Chains: B, L
Molecule details ›
Chains: B, L
Length: 215 amino acids
Theoretical weight: 23.6 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 71.177Å b: 86.628Å c: 155.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.259

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Citations

12 citation in other articles

6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Buckley et al. (2018)
11 more

1 mention without citation

An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants.
Guest et al. (2021)