› 4fqv

X-ray diffraction
5.75Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212417 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 327 amino acids
Theoretical weight: 35.89 KDa
Source organism: Influenza A virus (A/Netherlands/219/2003(H7N7))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6VMK1 (Residues: 19-341; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 176 amino acids
Theoretical weight: 20.33 KDa
Source organism: Influenza A virus (A/Netherlands/219/2003(H7N7))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6VMK1 (Residues: 342-517; Coverage: 31%)
Gene name: HA
Sequence domains: Haemagglutinin
Antibody CR9114 heavy chain Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 224 amino acids
Theoretical weight: 23.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Antibody CR9114 light chain Chains: L, M, N
Molecule details ›
Chains: L, M, N
Length: 216 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P42212
Unit cell:
a: 197.57Å b: 197.57Å c: 223.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.315 0.314 0.339
Expression systems:
  • Trichoplusia ni
  • Homo sapiens

Quick links

Citations

117 review citations

Broadly neutralizing antiviral antibodies.
Corti et al. (2013)
116 more

9 mentions without citation

Influenza virus antigenicity and broadly neutralizing epitopes.
Air GM. (2015)
8 more