› 4fxl

X-ray diffraction
1.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158314 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand ACT 1 x ACT
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 76.22Å b: 28.42Å c: 52.26Å
α: 90° β: 126.54° γ: 90°
R-values:
R R work R free
0.133 0.13 0.186
Expression system: Escherichia coli BL21

Quick links

Citations

27 review citations

Amyloid neuropathies.
Shin et al. (2012)
26 more

10 mentions without citation

The Early Phase of β2-Microglobulin Aggregation: Perspectives From Molecular Simulations.
Loureiro et al. (2020)
9 more