› 4gay

X-ray diffraction
2.65Å resolution

Structure of the broadly neutralizing antibody AP33

Released:
DOI: 10.2210/pdb4gay/pdb
PDB entry 4gay coloured by chain, front view.
PDB entry 4gay coloured by chain, side view.
PDB entry 4gay coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Toward a hepatitis C virus vaccine: the structural basis of hepatitis C virus neutralization by AP33, a broadly neutralizing antibody.
Potter JA, Owsianka AM, Jeffery N, Matthews DJ, Keck ZY, Lau P, Foung SK, Taylor GL, Patel AH
J Virol 86 12923-32 (2012)
PMID: 22993159

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213474 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NEUTRALIZING ANTIBODY AP33 HEAVY CHAIN Chains: A, H
Molecule details ›
Chains: A, H
Length: 218 amino acids
Theoretical weight: 23.68 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
NEUTRALIZING ANTIBODY AP33 LIGHT CHAIN Chains: B, L
Molecule details ›
Chains: B, L
Length: 218 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand PGE 2 x PGE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: I4122
Unit cell:
a: 90.874Å b: 90.874Å c: 459.156Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.243 0.32

Quick links

Citations

30 review citations

The past, present and future of neutralizing antibodies for hepatitis C virus.
Ball et al. (2014)
29 more

2 mentions without citation

Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.
Guest et al. (2018)
1 more