› 4gh4

X-ray diffraction
3Å resolution

Function and Biology Details

Reactions catalysed: 
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 240-mer (preferred)
PDBe Complex ID:
PDB-CPX-180205 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 22.96 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
  • Canonical: Q6PN23 (Residues: 726-935; Coverage: 9%)
Sequence domains: Picornavirus coat protein
Structure domains: Jelly Rolls
capsid protein VP2 Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 23.35 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
  • Canonical: Q6PN23 (Residues: 298-504; Coverage: 9%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
Capsid Chain: C
Molecule details ›
Chain: C
Length: 221 amino acids
Theoretical weight: 24.25 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
  • Canonical: Q9Q2N8 (Residues: 219-439; Coverage: 34%)
Sequence domains: picornavirus capsid protein
Structure domains: Jelly Rolls
capsid protein VP4 Chain: D
Molecule details ›
Chain: D
Length: 45 amino acids
Theoretical weight: 4.96 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
  • Canonical: Q9ILY1 (Residues: 15-85; Coverage: 6%)
Sequence domains: Viral protein VP4 subunit
Structure domains: Capsid protein VP4 superfamily, Picornavirus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: I222
Unit cell:
a: 328.2Å b: 341.8Å c: 363.75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.167 not available

Quick links

Citations

11 review citations

Foot-and-mouth disease.
Grubman et al. (2004)
10 more

9 mentions without citation

The pH stability of foot-and-mouth disease virus.
Yuan et al. (2017)
8 more