› 4gm9

X-ray diffraction
2.1Å resolution

Crystal structure of human WD repeat domain 5 with compound MM-401

Released:
DOI: 10.2210/pdb4gm9/pdb
PDB entry 4gm9 coloured by chain, front view.
PDB entry 4gm9 coloured by chain, side view.
PDB entry 4gm9 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Karatas H, Townsend EC, Chen Y, Bernard D, Liu L, Dou Y, Lei M, Wang S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158486 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61964 (Residues: 22-334; Coverage: 94%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
MM-401 Chains: E, F
Molecule details ›
Chains: E, F
Length: 5 amino acids
Theoretical weight: 606 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand ABA 2 x ABA
Ligand PG9 2 x PG9

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P1
Unit cell:
a: 46.904Å b: 47.242Å c: 68.896Å
α: 88.5° β: 89.5° γ: 74.53°
R-values:
R R work R free
0.161 0.159 0.208
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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