› 4gpo

X-ray diffraction
3.5Å resolution

Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor

Released:
DOI: 10.2210/pdb4gpo/pdb
PDB entry 4gpo coloured by chain, front view.
PDB entry 4gpo coloured by chain, side view.
PDB entry 4gpo coloured by chain, top view.
Source organism: Meleagris gallopavo
Primary publication:
Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state.
Huang J, Chen S, Zhang JJ, Huang XY
OpenAccess logo Nat Struct Mol Biol 20 419-25 (2013)
PMID: 23435379

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 35.75 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 31-368; Coverage: 64%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 229.66Å b: 79.59Å c: 69.04Å
α: 90° β: 101.83° γ: 90°
R-values:
R R work R free
0.312 0.31 0.355
Expression system: Trichoplusia ni

Quick links

Citations

38 review citations

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.
Ferré et al. (2014)
37 more

41 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
40 more