› 4hc6

X-ray diffraction
1.8Å resolution

Mycobacterium tuberculosis Rv2523cE77A x-ray structure solved with 1.8 angstrom resolution

Released:
DOI: 10.2210/pdb4hc6/pdb
PDB entry 4hc6 coloured by chain, front view.
PDB entry 4hc6 coloured by chain, side view.
PDB entry 4hc6 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Kim H-B, Han G-W, Hung L-W, Terwilliger CT, Kim C-Y, Integrated Center for Structure and Function Innovation (ISFI)

Function and Biology Details

Reaction catalysed: 
CoA-(4'-phosphopantetheine) + an apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + an [acyl-carrier-protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162067 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Holo-[acyl-carrier-protein] synthase Chain: A
Molecule details ›
Chain: A
Length: 129 amino acids
Theoretical weight: 13.83 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WQD3 (Residues: 2-130; Coverage: 99%)
Gene names: MTV009.08c, Rv2523c, acpS
Sequence domains: 4'-phosphopantetheinyl transferase superfamily
Structure domains: 4'-phosphopantetheinyl transferase domain

Ligands and Environments

4 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 7 x CL
Ligand NA 2 x NA
Ligand BR 3 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P213
Unit cell:
a: 73.272Å b: 73.272Å c: 73.272Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.212
Expression system: Escherichia coli BL21(DE3)

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