› 4ikg

X-ray diffraction
1.93Å resolution

Crystal structure of cell death-inducing DFFA-like effector c

Released:
DOI: 10.2210/pdb4ikg/pdb
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PDB entry 4ikg coloured by chain, front view.
PDB entry 4ikg coloured by chain, side view.
PDB entry 4ikg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.
Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P
OpenAccess logo Nat Commun 4 1594 (2013)
PMID: 23481402

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157415 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipid transferase CIDEC Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.17 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P56198 (Residues: 39-118; Coverage: 34%)
Gene names: Cidec, Fsp27
Sequence domains: CIDE-N domain
Structure domains: Ubiquitin-like (UB roll)

Ligands and Environments

1 bound ligand:
Ligand IOD 5 x IOD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P65
Unit cell:
a: 61.615Å b: 61.615Å c: 44.989Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.293 0.292 0.306
Expression system: Escherichia coli

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Citations

39 review citations

Dynamics and functions of lipid droplets.
Olzmann et al. (2019)
38 more

1 mention without citation

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.
Barneda et al. (2015)

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