› 4iuy

X-ray diffraction
2.38Å resolution

Crystal structure of short-chain dehydrogenase/reductase (apo-form) from A. baumannii clinical strain WM99C

Released:
DOI: 10.2210/pdb4iuy/pdb
PDB entry 4iuy coloured by chain, front view.
PDB entry 4iuy coloured by chain, side view.
PDB entry 4iuy coloured by chain, top view.
Source organism: Acinetobacter baumannii ACICU
Primary publication:
Structure of a short-chain dehydrogenase/reductase (SDR) within a genomic island from a clinical strain of Acinetobacter baumannii.
Shah BS, Tetu SG, Harrop SJ, Paulsen IT, Mabbutt BC
OpenAccess logo Acta Crystallogr F Struct Biol Commun 70 1318-23 (2014)
PMID: 25286932

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short chain dehydrogenase/reductase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 274 amino acids
Theoretical weight: 30.35 KDa
Source organism: Acinetobacter baumannii ACICU
Expression system: Escherichia coli BL21(DE3)
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 48 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 106.219Å b: 89.525Å c: 120.905Å
α: 90° β: 112.69° γ: 90°
R-values:
R R work R free
0.156 0.155 0.203
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The role of carbonyl reductase 1 in drug discovery and development.
Shi et al. (2017)
4 other articles

1 mention without citation

Structure of a short-chain dehydrogenase/reductase (SDR) within a genomic island from a clinical strain of Acinetobacter baumannii.
Shah et al. (2014)