› 4iv5

X-ray diffraction
2.1Å resolution

X-ray crystal structure of a putative aspartate carbamoyltransferase from Trypanosoma cruzi

Released:
DOI: 10.2210/pdb4iv5/pdb
PDB entry 4iv5 coloured by chain, front view.
PDB entry 4iv5 coloured by chain, side view.
PDB entry 4iv5 coloured by chain, top view.
Source organism: Trypanosoma cruzi strain CL Brener
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175461 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
aspartate carbamoyltransferase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 334 amino acids
Theoretical weight: 37.03 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4D3W3 (Residues: 1-326; Coverage: 100%)
Gene name: Tc00.1047053508375.30
Sequence domains:
Structure domains: Aspartate/ornithine carbamoyltransferase

Ligands and Environments

3 bound ligands:
Ligand PO4 6 x PO4
Ligand UNX 11 x UNX
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 83.98Å b: 134.55Å c: 159.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.238
Expression system: Escherichia coli

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