› 4jf5

X-ray diffraction
1.15Å resolution

Structure of OXA-23 at pH 4.1

Released:
DOI: 10.2210/pdb4jf5/pdb
PDB entry 4jf5 coloured by chain, front view.
PDB entry 4jf5 coloured by chain, side view.
PDB entry 4jf5 coloured by chain, top view.
Source organism: Acinetobacter baumannii
Primary publication:
Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.
Smith CA, Antunes NT, Stewart NK, Toth M, Kumarasiri M, Chang M, Mobashery S, Vakulenko SB
Chem Biol 20 1107-15 (2013)
PMID: 24012371

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192203 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

2 bound ligands:
Ligand FLC 1 x FLC
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 132.919Å b: 49.651Å c: 44.121Å
α: 90° β: 96.97° γ: 90°
R-values:
R R work R free
0.141 0.14 0.162
Expression system: Escherichia coli

Quick links

Citations

15 review citations

OXA β-lactamases.
Evans et al. (2014)
14 more

4 mentions without citation

A review on the mechanistic details of OXA enzymes of ESKAPE pathogens.
Avci et al. (2023)
3 more