› 4jno

X-ray diffraction
3Å resolution

Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL) Region II in complex with sialyllactose

Released:
DOI: 10.2210/pdb4jno/pdb
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Source organism: Plasmodium falciparum
Primary publication:
Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL.
Malpede BM, Lin DH, Tolia NH
J Biol Chem 288 12406-15 (2013)
PMID: 23508963

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte binding antigen 140 Chain: A
Molecule details ›
Chain: A
Length: 615 amino acids
Theoretical weight: 73.45 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WS31 (Residues: 141-755; Coverage: 51%)
Sequence domains: Duffy binding domain
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand SIA 2 x SIA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 64.95Å b: 76.03Å c: 81.43Å
α: 90° β: 96.93° γ: 90°
R-values:
R R work R free
0.22 0.218 0.255
Expression system: Escherichia coli

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Citations

12 review citations

Biological roles of glycans.
Varki A. (2017)
11 more

7 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
6 more

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