Function and Biology Details
Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Alpha/Beta hydrolase fold
- Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV
- Peptidase S9, serine active site
- Peptidase S9, prolyl oligopeptidase, catalytic domain
- Dipeptidylpeptidase IV, N-terminal domain
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Spike glycoprotein and Dipeptidyl peptidase 4 (preferred)
PDBe Complex ID:
PDB-CPX-125456 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Dipeptidyl peptidase 4
Molecule details ›
Chain: A
Length: 739 amino acids
Theoretical weight: 85.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Structure domains:
Length: 739 amino acids
Theoretical weight: 85.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P27487 (Residues: 39-766; Coverage: 95%)
Sequence domains:
Structure domains:
Spike glycoprotein
Molecule details ›
Chain: B
Length: 251 amino acids
Theoretical weight: 27.6 KDa
Source organism: Human betacoronavirus 2c EMC/2012
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:
Length: 251 amino acids
Theoretical weight: 27.6 KDa
Source organism: Human betacoronavirus 2c EMC/2012
Expression system: Trichoplusia ni
UniProt:
- Canonical: K0BRG7 (Residues: 367-606; Coverage: 18%)
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Structure domains:
