› 4ldc

X-ray diffraction
1.26Å resolution

Crystal Structure of DOC2B C2B domain

Released:
DOI: 10.2210/pdb4ldc/pdb
PDB entry 4ldc coloured by chain, front view.
PDB entry 4ldc coloured by chain, side view.
PDB entry 4ldc coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The C2B domain is the primary Ca2+ sensor in DOC2B: a structural and functional analysis.
Giladi M, Michaeli L, Almagor L, Bar-On D, Buki T, Ashery U, Khananshvili D, Hirsch JA
J Mol Biol 425 4629-41 (2013)
PMID: 23994332

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159748 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Double C2-like domain-containing protein beta Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 16.97 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P70610 (Residues: 265-412; Coverage: 36%)
Gene name: Doc2b
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand FLC 1 x FLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 90.802Å b: 40.091Å c: 36.922Å
α: 90° β: 105.47° γ: 90°
R-values:
R R work R free
0.128 0.127 0.144
Expression system: Escherichia coli

Quick links

Citations

10 citation in other articles

Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release.
Courtney et al. (2018)
9 more

5 mentions without citation

DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.
Zhang et al. (2019)
4 more