› 4mqk

X-ray diffraction
2.24Å resolution

Carbonmonoxy Structure of the Human Fetal Hemoglobin Mutant HbF Toms River alphawtgammaV67M

Released:
DOI: 10.2210/pdb4mqk/pdb
PDB entry 4mqk coloured by chain, front view.
PDB entry 4mqk coloured by chain, side view.
PDB entry 4mqk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Soman J, Olson JS

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159679 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit gamma-2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 146 amino acids
Theoretical weight: 16.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69892 (Residues: 2-147; Coverage: 99%)
Gene name: HBG2
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand HEM 8 x HEM
Ligand CMO 6 x CMO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 106.04Å b: 52.229Å c: 106.381Å
α: 90° β: 114.27° γ: 90°
R-values:
R R work R free
0.177 0.175 0.232
Expression system: Escherichia coli

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