› 4muz

X-ray diffraction
1.39Å resolution

Crystal structure of orotidine 5'-monophosphate decarboxylase from Archaeoglobus fulgidus complexed with inhibitor BMP

Released:
DOI: 10.2210/pdb4muz/pdb
PDB entry 4muz coloured by chain, front view.
PDB entry 4muz coloured by chain, side view.
PDB entry 4muz coloured by chain, top view.
Source organism: Archaeoglobus fulgidus
Entry authors: Fedorov AA, Fedorov EV, Desai B, Gerlt JA, Almo SC

Function and Biology Details

Reaction catalysed: 
Orotidine 5'-phosphate = UMP + CO(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128114 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orotidine 5'-phosphate decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 24.74 KDa
Source organism: Archaeoglobus fulgidus
Expression system: Escherichia coli
UniProt:
  • Canonical: O29333 (Residues: 1-209; Coverage: 100%)
Gene names: AF_0929, pyrF
Sequence domains: Orotidine 5'-phosphate decarboxylase / HUMPS family
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand BMP 2 x BMP
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 54.933Å b: 58.48Å c: 56.914Å
α: 90° β: 94.98° γ: 90°
R-values:
R R work R free
0.162 0.162 0.186
Expression system: Escherichia coli

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