› 4mw8

X-ray diffraction
3.26Å resolution

Structural Basis for Ca2+ Selectivity of a Voltage-gated Calcium Channel

Released:
DOI: 10.2210/pdb4mw8/pdb
PDB entry 4mw8 coloured by chain, front view.
PDB entry 4mw8 coloured by chain, side view.
PDB entry 4mw8 coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Structural basis for Ca2+ selectivity of a voltage-gated calcium channel.
Tang L, Gamal El-Din TM, Payandeh J, Martinez GQ, Heard TM, Scheuer T, Zheng N, Catterall WA
OpenAccess logo Nature 505 56-61 (2014)
PMID: 24270805

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-501454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 237 amino acids
Theoretical weight: 27.46 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-219; Coverage: 82%)
Gene name: Abu_1752
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand PX4 16 x PX4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 229.218Å b: 124.883Å c: 124.763Å
α: 90° β: 122.95° γ: 90°
R-values:
R R work R free
0.278 0.276 0.314
Expression system: Trichoplusia ni

Quick links

Citations

47 review citations

Store-Operated Calcium Channels.
Prakriya et al. (2015)
46 more

6 mentions without citation

Proton channel models filling the gap between experimental data and the structural rationale.
Pupo et al. (2014)
5 more