› 4mzc

X-ray diffraction
0.95Å resolution

Atomic Resolution Structure of PfGrx1

Released:
DOI: 10.2210/pdb4mzc/pdb
PDB entry 4mzc coloured by chain, front view.
PDB entry 4mzc coloured by chain, side view.
PDB entry 4mzc coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.
Yogavel M, Tripathi T, Gupta A, Banday MM, Rahlfs S, Becker K, Belrhali H, Sharma A
Acta Crystallogr D Biol Crystallogr 70 91-100 (2014)
PMID: 24419382

Function and Biology Details

Reaction catalysed: 
Arsenate + glutathione + glutaredoxin = arsenite + a glutaredoxin-glutathione disulfide + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-1 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.44 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli M15
UniProt:
  • Canonical: Q9NLB2 (Residues: 1-111; Coverage: 100%)
Gene name: PF3D7_0306300
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand MPO 1 x MPO
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P3221
Unit cell:
a: 47.971Å b: 47.971Å c: 82.473Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.104 0.104 0.111
Expression system: Escherichia coli M15

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Citations

1 review citation

The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.
Guevara-Flores et al. (2017)
5 other articles

4 mentions without citation

Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Millán et al. (2015)
3 more