› 4n4g

X-ray diffraction
1.95Å resolution

Crystal structure of the Bromo-PWWP of the mouse zinc finger MYND-type containing 11 isoform alpha

Released:
DOI: 10.2210/pdb4n4g/pdb
PDB entry 4n4g coloured by chain, front view.
PDB entry 4n4g coloured by chain, side view.
PDB entry 4n4g coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.
Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W, Li H, Shi X
Nature 508 263-8 (2014)
PMID: 24590075

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185909 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger MYND domain-containing protein 11 Chain: A
Molecule details ›
Chain: A
Length: 252 amino acids
Theoretical weight: 29.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8R5C8 (Residues: 154-371; Coverage: 36%)
Gene name: Zmynd11
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 1W2B
Spacegroup: P212121
Unit cell:
a: 54.919Å b: 64.267Å c: 75.587Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.226
Expression system: Escherichia coli

Quick links

Citations

71 review citations

Histone exchange, chromatin structure and the regulation of transcription.
Venkatesh et al. (2015)
70 more

4 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
3 more