› 4n8n

X-ray diffraction
1.87Å resolution

Crystal structure of Mycobacterial FtsX extracellular domain

Released:
DOI: 10.2210/pdb4n8n/pdb
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Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC.
Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T
Proc Natl Acad Sci U S A 111 8037-42 (2014)
PMID: 24843173

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsX Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 115 amino acids
Theoretical weight: 12.96 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WG19 (Residues: 45-157; Coverage: 38%)
Gene names: MTCY164.12c, Rv3101c, ftsX
Sequence domains: FtsX extracellular domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

1 bound ligand:
Ligand K 2 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21212
Unit cell:
a: 106.248Å b: 150.009Å c: 28.658Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.233
Expression system: Escherichia coli

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Citations

10 review citations

How sisters grow apart: mycobacterial growth and division.
Kieser et al. (2014)
9 more

5 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
4 more

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