› 4n8o

X-ray diffraction
2.3Å resolution

Crystal structure of Mycobacterial FtsX extracellular domain, bromide derivative

Released:
DOI: 10.2210/pdb4n8o/pdb
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PDB entry 4n8o coloured by chain, front view.
PDB entry 4n8o coloured by chain, side view.
PDB entry 4n8o coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC.
Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T
Proc Natl Acad Sci U S A 111 8037-42 (2014)
PMID: 24843173

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsX Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 12.96 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WG19 (Residues: 45-157; Coverage: 38%)
Gene names: MTCY164.12c, Rv3101c, ftsX
Sequence domains: FtsX extracellular domain
Structure domains: Alpha-Beta Plaits

Ligands and Environments

2 bound ligands:
Ligand BR 4 x BR
Ligand K 4 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I4
Unit cell:
a: 133.167Å b: 133.167Å c: 28.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.239
Expression system: Escherichia coli

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Citations

11 review citations

How sisters grow apart: mycobacterial growth and division.
Kieser et al. (2014)
10 more

3 mentions without citation

The ATP-Binding Cassette (ABC) Transport Systems in Mycobacterium tuberculosis: Structure, Function, and Possible Targets for Therapeutics.
Cassio Barreto de Oliveira et al. (2020)
2 more

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