› 4nej

X-ray diffraction
1.92Å resolution

Small molecular fragment bound to crystal contact interface of Interleukin-2

Released:
DOI: 10.2210/pdb4nej/pdb
PDB entry 4nej coloured by chain, front view.
PDB entry 4nej coloured by chain, side view.
PDB entry 4nej coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Brenke R, Jehle S, Vajda S, Allen KN, Kozakov D

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-2 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60568 (Residues: 24-153; Coverage: 98%)
Gene name: IL2
Sequence domains: Interleukin 2
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand 2K1 2 x 2K1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21212
Unit cell:
a: 48.069Å b: 86.626Å c: 32.137Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.258
Expression system: Escherichia coli

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