4nf5

X-ray diffraction
1.9Å resolution

Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152907 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.34 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-544, 663-800; Coverage: 31%)
Gene names: Grin1, Nmdar1
Sequence domains:
Structure domains: Periplasmic binding protein-like II
Glutamate receptor ionotropic, NMDA 2A Chain: B
Molecule details ›
Chain: B
Length: 283 amino acids
Theoretical weight: 31.79 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00959 (Residues: 402-802; Coverage: 20%)
Gene name: Grin2a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 55.029Å b: 87.344Å c: 121.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.213
Expression system: Escherichia coli