› 4nun

X-ray diffraction
2.2Å resolution

Crystal structure of copper-bound Na-ASP-2

Released:
DOI: 10.2210/pdb4nun/pdb
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PDB entry 4nun coloured by chain, front view.
PDB entry 4nun coloured by chain, side view.
PDB entry 4nun coloured by chain, top view.
Source organism: Necator americanus
Primary publication:
Probing the equatorial groove of the hookworm protein and vaccine candidate antigen, Na-ASP-2.
Mason L, Tribolet L, Simon A, von Gnielinski N, Nienaber L, Taylor P, Willis C, Jones MK, Sternberg PW, Gasser RB, Loukas A, Hofmann A
Int J Biochem Cell Biol 50 146-55 (2014)
PMID: 24631931

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SCP domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 22.65 KDa
Source organism: Necator americanus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: J9ULM6 (Residues: 1-210; Coverage: 100%)
Gene name: ASP2
Sequence domains: Cysteine-rich secretory protein family
Structure domains: CAP

Ligands and Environments

1 bound ligand:
Ligand CU 1 x CU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 36.953Å b: 51.267Å c: 43.288Å
α: 90° β: 93.96° γ: 90°
R-values:
R R work R free
0.178 0.175 0.231
Expression system: Komagataella pastoris

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Citations

10 citation in other articles

Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.
Tribolet et al. (2015)
9 more

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