4oar

X-ray diffraction
2.41Å resolution

Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-139040 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Progesterone receptor Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 29.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06401 (Residues: 678-933; Coverage: 27%)
Gene names: NR3C3, PGR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor corepressor 2 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y618 (Residues: 2335-2351; Coverage: 1%)
Gene names: CTG26, NCOR2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P3221
Unit cell:
a: 87.18Å b: 87.18Å c: 90.91Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.234
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided