› 4p10

X-ray diffraction
2Å resolution

pro-carboxypeptidase U In Complex With 5-(3-aminopropyl)-1-propyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid

Released:
DOI: 10.2210/pdb4p10/pdb
PDB entry 4p10 coloured by chain, front view.
PDB entry 4p10 coloured by chain, side view.
PDB entry 4p10 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).
Brink M, Dahlén A, Olsson T, Polla M, Svensson T
Bioorg Med Chem 22 2261-8 (2014)
PMID: 24588961

Function and Biology Details

Reaction catalysed: 
Release of C-terminal Arg and Lys from a polypeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188550 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carboxypeptidase B2 Chain: A
Molecule details ›
Chain: A
Length: 404 amino acids
Theoretical weight: 46.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96IY4 (Residues: 23-423; Coverage: 100%)
Gene name: CPB2
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 2B8 1 x 2B8
Ligand ZN 1 x ZN
Ligand DMS 1 x DMS
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 49.576Å b: 49.243Å c: 95.048Å
α: 90° β: 93.12° γ: 90°
R-values:
R R work R free
0.186 0.184 0.218
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Structure-function relationships in thrombin-activatable fibrinolysis inhibitor.
Plug et al. (2016)
1 more

4 mentions without citation

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review.
Sillen et al. (2021)
3 more