› 4p3a

X-ray diffraction
1.4Å resolution

Crystal structure of the mouse C5a anaphylatoxin

Released:
DOI: 10.2210/pdb4p3a/pdb
PDB entry 4p3a coloured by chain, front view.
PDB entry 4p3a coloured by chain, side view.
PDB entry 4p3a coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional characterization of human and murine C5a anaphylatoxins.
Schatz-Jakobsen JA, Yatime L, Larsen C, Petersen SV, Klos A, Andersen GR
OpenAccess logo Acta Crystallogr D Biol Crystallogr 70 1704-17 (2014)
PMID: 24914981

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C5a anaphylatoxin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 79 amino acids
Theoretical weight: 9.05 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P06684 (Residues: 679-755; Coverage: 5%)
Gene names: C5, Hc
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

1 bound ligand:
Ligand FMT 16 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P43
Unit cell:
a: 54.95Å b: 54.95Å c: 117.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.144 0.174
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
5 more

2 mentions without citation

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Yatime et al. (2015)
1 more