› 4p5i

X-ray diffraction
2.25Å resolution

Crystal structure of the chemokine binding protein from orf virus

Released:
DOI: 10.2210/pdb4p5i/pdb
PDB entry 4p5i coloured by chain, front view.
PDB entry 4p5i coloured by chain, side view.
PDB entry 4p5i coloured by chain, top view.
Source organism: Orf virus
Primary publication:
Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.
Couñago RM, Knapp KM, Nakatani Y, Fleming SB, Corbett M, Wise LM, Mercer AA, Krause KL
Structure 23 1199-213 (2015)
PMID: 26095031

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Chemokine binding protein Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 29.58 KDa
Source organism: Orf virus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2F862 (Residues: 17-286; Coverage: 94%)
Sequence domains: Viral chemokine binding protein

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P6522
Unit cell:
a: 76.25Å b: 76.25Å c: 281.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.206 0.233
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Targeting Chemokine-Glycosaminoglycan Interactions to Inhibit Inflammation.
Crijns et al. (2020)
6 more

3 mentions without citation

The binding and specificity of chemokine binding proteins, through the lens of experiment and computation.
Stark et al. (2022)
2 more