› 4p80

X-ray diffraction
1.6Å resolution

Structure of ancestral PyrR protein (AncGREENPyrR)

Released:
DOI: 10.2210/pdb4p80/pdb
PDB entry 4p80 coloured by chain, front view.
PDB entry 4p80 coloured by chain, side view.
PDB entry 4p80 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Evolution of oligomeric state through allosteric pathways that mimic ligand binding.
Perica T, Kondo Y, Tiwari SP, McLaughlin SH, Kemplen KR, Zhang X, Steward A, Reuter N, Clarke J, Teichmann SA
Science 346 1254346 (2014)
PMID: 25525255

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164989 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ancestral PyrR protein (Green) Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 20.05 KDa
Source organism: synthetic construct
Expression system: Bacteria
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 123.43Å b: 67.03Å c: 56.82Å
α: 90° β: 101.06° γ: 90°
R-values:
R R work R free
0.216 0.215 0.248
Expression system: Bacteria

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Citations

13 review citations

Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance.
Hove-Jensen et al. (2017)
12 more

1 mention without citation

Evolution of oligomeric state through allosteric pathways that mimic ligand binding.
Perica et al. (2014)